PDBsum entry 4dck

Transport protein/signaling protein

PDB id: 4dck

Contents

Protein chains

153 a.a.

134 a.a.

148 a.a.

Metals

_MG ×3

Waters ×202

PDB id:

4dck

Name:

Transport protein/signaling protein

Title:

Crystal structure of thE C-terminus of voltage-gated sodium channel in complex with fgf13 and cam

Structure:

Sodium channel protein type 5 subunit alpha. Chain: a. Fragment: c-terminal domain of nav1.5. Synonym: hh1, sodium channel protein cardiac muscle subunit alpha, sodium channel protein type v subunit alpha, voltage-gated sodium channel subunit alpha nav1.5. Engineered: yes. Calmodulin. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: scn5a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: calm1, calm, cam, cam1, calm2, cam2, camb, calm3, calml2, cam3, camc, camiii. Gene: fgf13, fhf2.

Resolution:

2.20Å R-factor: 0.211 R-free: 0.227

Authors:

B.C.Chung,C.Wang,H.Yan,G.S.Pitt,S.Y.Lee

Key ref:

C.Wang et al. (2012). Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. Structure, 20, 1167-1176. PubMed id: 22705208

Date:

17-Jan-12 Release date: 27-Jun-12

Protein chain

Q14524  (SCN5A_HUMAN) -  Sodium channel protein type 5 subunit alpha from Homo sapiens

Seq: 2016 a.a.

Struc: 153 a.a.

Protein chain

P0DP23  (CALM1_HUMAN) -  Calmodulin-1 from Homo sapiens

Seq: 149 a.a.

Struc: 134 a.a.

Protein chain

Q92913  (FGF13_HUMAN) -  Fibroblast growth factor 13 from Homo sapiens

Seq: 245 a.a.

Struc: 148 a.a.

Structure 20:1167-1176 (2012)

PubMed id: 22705208

Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin.

C.Wang, B.C.Chung, H.Yan, S.Y.Lee, G.S.Pitt.

ABSTRACT

No abstract given.