PDBsum entry 4d9r

Hydrolase/immune system

PDB id: 4d9r

Contents

Protein chains

228 a.a.

214 a.a.

218 a.a.

Metals

_CL ×2

Waters ×349

PDB id:

4d9r

Name:

Hydrolase/immune system

Title:

Inhibiting alternative pathway complement activation by targeting the exosite on factor d

Structure:

Complement factor d. Chain: a, b. Synonym: adipsin, c3 convertase activator, properdin factor d. Engineered: yes. Fab light chain. Chain: l, d. Engineered: yes. Fab heavy chain. Chain: h, e.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cfd, df, factor d, pfd. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: igkc. Gene: ighg1. Expression_system_taxid: 562

Resolution:

2.42Å R-factor: 0.215 R-free: 0.251

Authors:

J.M.Murray,C.Wiesmann

Key ref:

K.J.Katschke et al. (2012). Inhibiting alternative pathway complement activation by targeting the factor D exosite. J Biol Chem, 287, 12886-12892. PubMed id: 22362762

Date:

11-Jan-12 Release date: 22-Feb-12

Protein chains

P00746  (CFAD_HUMAN) -  Complement factor D from Homo sapiens

Seq: 253 a.a.

Struc: 228 a.a.

Protein chains

P01834  (IGKC_HUMAN) -  Immunoglobulin kappa constant from Homo sapiens

Seq: 107 a.a.

Struc: 214 a.a.

Protein chains

P01857  (IGHG1_HUMAN) -  Immunoglobulin heavy constant gamma 1 from Homo sapiens

Seq: 399 a.a.

Struc: 218 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.21.46 - complement factor D.
• Reaction: Cleaves component factor B (Arg-|-Lys) when in complex with C3b or with cobra venom factor (CVF).

J Biol Chem 287:12886-12892 (2012)

PubMed id: 22362762

Inhibiting alternative pathway complement activation by targeting the factor D exosite.

K.J.Katschke, P.Wu, R.Ganesan, R.F.Kelley, M.A.Mathieu, P.E.Hass, J.Murray, D.Kirchhofer, C.Wiesmann, M.van Lookeren Campagne.

ABSTRACT

No abstract given.