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PDBsum entry 4d6v
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Signaling protein
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PDB id
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4d6v
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References listed in PDB file
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Key reference
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Title
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Crystal structure of gib2, A signal-Transducing protein scaffold associated with ribosomes in cryptococcus neoformans.
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Authors
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R.Ero,
V.T.Dimitrova,
Y.Chen,
W.Bu,
S.Feng,
T.Liu,
P.Wang,
C.Xue,
S.M.Tan,
Y.G.Gao.
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Ref.
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Sci Rep, 2015,
5,
8688.
[DOI no: ]
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PubMed id
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Abstract
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The atypical Gβ-like/RACK1 Gib2 protein promotes cAMP signalling that plays a
central role in regulating the virulence of Cryptococcus neoformans. Gib2
contains a seven-bladed β transducin structure and is emerging as a scaffold
protein interconnecting signalling pathways through interactions with various
protein partners. Here, we present the crystal structure of Gib2 at a 2.2-Å
resolution. The structure allows us to analyse the association between Gib2 and
the ribosome, as well as to identify the Gib2 amino acid residues involved in
ribosome binding. Our studies not only suggest that Gib2 has a role in protein
translation but also present Gib2 as a physical link at the crossroads of
various regulatory pathways important for the growth and virulence of C.
neoformans.
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