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UniProt functional annotation for D6R8X8 | ||
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| UniProt code: D6R8X8. |
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| Organism: | |
Microbacterium liquefaciens (Aureobacterium liquefaciens). |
| Taxonomy: | |
Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae; Microbacterium. |
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| Function: | |
Nucleobase-proton symporter that mediates the sodium- dependent binding and uptake of 5-aryl-substituted hydantoin compounds (PubMed:16621827, PubMed:24952894). 5-indolyl methyl hydantoin and 5- benzyl hydantoin are the preferred substrates, with selectivity for a hydrophobic substituent in position 5 of hydantoin and for the L isomer over the D isomer (PubMed:16621827, PubMed:24952894). {ECO:0000269|PubMed:16621827, ECO:0000269|PubMed:24952894, ECO:0000305|PubMed:16116274}. |
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| Activity regulation: | |
Inhibited by dinitrophenol, 5-(2-naphthylmethyl)- D-hydantoin (D-NMH), 5-(2-naphthylmethyl)-L-hydantoin (L-NMH), 5- bromovinylhydantoin (BVH) and 5-indolylmethyl-L-hydantoin (L-IMH) (PubMed:16621827, PubMed:24952894). The affinity of benzyl-hydantoin is increased over 10-fold in the presence of 15 mM of sodium (PubMed:18927357). {ECO:0000269|PubMed:16621827, ECO:0000269|PubMed:18927357, ECO:0000269|PubMed:24952894}. |
| Biophysicochemical properties: | |
pH dependence: Optimum pH is 6.6. {ECO:0000269|PubMed:16621827}; |
| Subcellular location: | |
Membrane {ECO:0000269|PubMed:16621827}; Multi- pass membrane protein {ECO:0000305|PubMed:18927357, ECO:0000305|PubMed:20413494}. |
| Similarity: | |
Belongs to the purine-cytosine permease (2.A.39) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.