UniProt functional annotation for Q9V3J8



	UniProt functional annotation for Q9V3J8

UniProt code: Q9V3J8.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. {ECO:0000269|PubMed:25310983}.

Subunit: Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1 (PubMed:21694722). Interacts with Set1 (PubMed:21694722, PubMed:21875999, PubMed:22048023). Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6 (PubMed:21875999). Component of the Ada2a-containing (ATAC) complex composed of at least Ada2a, Atac1, Hcf, Ada3, Gcn5, Mocs2B, Charac-14, Atac3, Atac2, NC2beta and wds (PubMed:18327268). Interacts with Nup98 (PubMed:25310983). {ECO:0000269|PubMed:18327268, ECO:0000269|PubMed:21694722, ECO:0000269|PubMed:21875999, ECO:0000269|PubMed:22048023, ECO:0000269|PubMed:25310983}.

Subcellular location: Nucleus {ECO:0000269|PubMed:18327268, ECO:0000269|PubMed:21694722}.

Tissue specificity: Expressed in imaginal disks, larval brain, nurse cells, spermatogonia and spermatocytes. {ECO:0000269|PubMed:12471440}.

Developmental stage: Expressed at all stages of development. {ECO:0000269|PubMed:12471440}.

Disruption phenotype: Larval lethal (PubMed:12471440). Conditional RNAi-mediated knockdown in larval wing imaginal disks results in reduced levels of trimethylated 'Lys-4' in histone H3 (PubMed:25310983). {ECO:0000269|PubMed:12471440, ECO:0000269|PubMed:25310983}.

Similarity: Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. {ECO:0000269\|PubMed:25310983}.


Subunit:		Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1 (PubMed:21694722). Interacts with Set1 (PubMed:21694722, PubMed:21875999, PubMed:22048023). Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6 (PubMed:21875999). Component of the Ada2a-containing (ATAC) complex composed of at least Ada2a, Atac1, Hcf, Ada3, Gcn5, Mocs2B, Charac-14, Atac3, Atac2, NC2beta and wds (PubMed:18327268). Interacts with Nup98 (PubMed:25310983). {ECO:0000269\|PubMed:18327268, ECO:0000269\|PubMed:21694722, ECO:0000269\|PubMed:21875999, ECO:0000269\|PubMed:22048023, ECO:0000269\|PubMed:25310983}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:18327268, ECO:0000269\|PubMed:21694722}.
Tissue specificity:		Expressed in imaginal disks, larval brain, nurse cells, spermatogonia and spermatocytes. {ECO:0000269\|PubMed:12471440}.
Developmental stage:		Expressed at all stages of development. {ECO:0000269\|PubMed:12471440}.
Disruption phenotype:		Larval lethal (PubMed:12471440). Conditional RNAi-mediated knockdown in larval wing imaginal disks results in reduced levels of trimethylated 'Lys-4' in histone H3 (PubMed:25310983). {ECO:0000269\|PubMed:12471440, ECO:0000269\|PubMed:25310983}.
Similarity:		Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.