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UniProt functional annotation for Q03195 | ||
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| UniProt code: Q03195. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits. {ECO:0000269|PubMed:15277527, ECO:0000269|PubMed:15660134, ECO:0000269|PubMed:15660135}. |
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| Subunit: | |
Component of the multifactor complex (MFC) composed of at least RLI1, the eIF2 subunit SUI2, TIF5/eIF5, and the eIF3 subunits PRT1, HCR1, NIP1, RPG1, TIF34 and TIF35. The complex associates with pre-initiation complexes. Interacts with the complex YAE1:LTO1; the complex bridges the interaction between the CIA complex and RLI1 (PubMed:23318452). {ECO:0000269|PubMed:15277527, ECO:0000269|PubMed:15660134, ECO:0000269|PubMed:15660135, ECO:0000269|PubMed:23318452}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15277527, ECO:0000269|PubMed:15660134, ECO:0000269|PubMed:15660135}. Nucleus {ECO:0000269|PubMed:15277527, ECO:0000269|PubMed:15660134, ECO:0000269|PubMed:15660135}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:15660134, ECO:0000269|PubMed:15660135}. |
| Miscellaneous: | |
Present with 6280 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the ABC transporter superfamily. ABCE family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.