UniProt functional annotation for Q9ULU4



	UniProt functional annotation for Q9ULU4

UniProt code: Q9ULU4.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. {ECO:0000269|PubMed:27477906}.

Subunit: Interacts in vitro with PRKCB1 (PubMed:11003709). Interacts with KDM5D and KDM1A (PubMed:27477906). Interacts with histone H3 (via N-terminus) that is both methylated at 'Lys-4' (H3K4me1) and acetylated at 'Lys-14' (H3K14ac), and with histone H3 (via N-terminus) unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-14' (H3K14ac) (PubMed:27477906). Interacts (via PHD-type Zinc finger, Bromo and PWWP domains) with DBN1 (via ADF-H domain); the interaction leads to sequestering of ZMYND8 in the cytoplasm (PubMed:28966017). {ECO:0000269|PubMed:11003709, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:28966017}.

Subcellular location: Nucleus {ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:28966017}. Cytoplasm {ECO:0000269|PubMed:28966017}. Note=Sequestered in the cytoplasm through the interaction with DBN1. {ECO:0000269|PubMed:28966017}.

Tissue specificity: Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).

Sequence caution: Sequence=AAC72244.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA86439.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. {ECO:0000269\|PubMed:27477906}.


Subunit:		Interacts in vitro with PRKCB1 (PubMed:11003709). Interacts with KDM5D and KDM1A (PubMed:27477906). Interacts with histone H3 (via N-terminus) that is both methylated at 'Lys-4' (H3K4me1) and acetylated at 'Lys-14' (H3K14ac), and with histone H3 (via N-terminus) unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-14' (H3K14ac) (PubMed:27477906). Interacts (via PHD-type Zinc finger, Bromo and PWWP domains) with DBN1 (via ADF-H domain); the interaction leads to sequestering of ZMYND8 in the cytoplasm (PubMed:28966017). {ECO:0000269\|PubMed:11003709, ECO:0000269\|PubMed:27477906, ECO:0000269\|PubMed:28966017}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:27477906, ECO:0000269\|PubMed:28966017}. Cytoplasm {ECO:0000269\|PubMed:28966017}. Note=Sequestered in the cytoplasm through the interaction with DBN1. {ECO:0000269\|PubMed:28966017}.
Tissue specificity:		Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).
Sequence caution:		Sequence=AAC72244.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA86439.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};