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PDBsum entry 4cn9
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Structural protein
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PDB id
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4cn9
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References listed in PDB file
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Key reference
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Title
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Structural and functional features of a collagen-Binding matrix protein from the mussel byssus.
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Authors
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M.H.Suhre,
M.Gertz,
C.Steegborn,
T.Scheibel.
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Ref.
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Nat Commun, 2014,
5,
3392.
[DOI no: ]
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PubMed id
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Abstract
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Blue mussels adhere to surfaces by the byssus, a holdfast structure composed of
individual threads representing a collagen fibre reinforced composite. Here, we
present the crystal structure and function of one of its matrix proteins, the
proximal thread matrix protein 1, which is present in the proximal section of
the byssus. The structure reveals two von Willebrand factor type A domains
linked by a two-β-stranded linker yielding a novel structural arrangement. In
vitro, the protein binds heterologous collagens with high affinity and affects
collagen assembly, morphology and arrangement of its fibrils. By providing
charged surface clusters as well as insufficiently coordinated metal ions, the
proximal thread matrix protein 1 might interconnect other byssal proteins and
thereby contribute to the integrity of the byssal threads in vivo. Moreover, the
protein could be used for adjusting the mechanical properties of collagen
materials, a function likely important in the natural byssus.
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