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PDBsum entry 4cmh
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Hydrolase/immune system
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PDB id
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4cmh
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Contents |
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240 a.a.
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216 a.a.
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213 a.a.
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PDB id:
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| Name: |
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Hydrolase/immune system
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Title:
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Crystal structure of cd38 with a novel cd38-targeting antibody sar650984
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Structure:
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Adp-ribosyl cyclase 1. Chain: a. Fragment: extracellular domain, residues 45-300. Synonym: cyclic adp-ribose hydrolase 1, cadpr hydrolase 1, t10, cd38, acyl-ribose cyclase 1. Engineered: yes. Mutation: yes. Heavy chain of sar650984-fab fragment. Chain: b.
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Source:
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Homo sapiens. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293t. Mus musculus. House mouse. Organism_taxid: 10090. Organism_taxid: 10090
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Resolution:
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1.53Å
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R-factor:
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0.189
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R-free:
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0.208
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Authors:
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J.Deckert,M.C.Wetzel,P.U.Park,L.M.Bartle,A.Skaletskaya,V.Goldmacher, F.Vallee,Q.Zhouliu,P.Ferrari,S.Pouzieux,C.Lahoute,C.Dumontet, A.Plesa,M.Chiron,P.Lejeune,T.Chittenden,V.Blanc
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Key ref:
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J.Deckert
et al.
(2014).
SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies.
Clin Cancer Res,
20,
4574-4583.
PubMed id:
DOI:
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Date:
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15-Jan-14
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Release date:
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16-Jul-14
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PROCHECK
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Headers
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References
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P28907
(CD38_HUMAN) -
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 from Homo sapiens
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Seq:
Struc:
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300 a.a.
240 a.a.*
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Enzyme class 2:
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Chain A:
E.C.2.4.99.20
- 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase.
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Reaction:
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nicotinate + NADP+ = nicotinate-adenine dinucleotide phosphate + nicotinamide
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nicotinate
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+
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NADP(+)
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=
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nicotinate-adenine dinucleotide phosphate
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+
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nicotinamide
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Enzyme class 3:
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Chain A:
E.C.3.2.2.-
- ?????
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Enzyme class 4:
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Chain A:
E.C.3.2.2.6
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
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Reaction:
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NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
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NAD(+)
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+
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H2O
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=
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ADP-D-ribose
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+
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nicotinamide
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Clin Cancer Res
20:4574-4583
(2014)
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PubMed id:
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SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies.
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J.Deckert,
M.C.Wetzel,
L.M.Bartle,
A.Skaletskaya,
V.S.Goldmacher,
F.Vallée,
Q.Zhou-Liu,
P.Ferrari,
S.Pouzieux,
C.Lahoute,
C.Dumontet,
A.Plesa,
M.Chiron,
P.Lejeune,
T.Chittenden,
P.U.Park,
V.Blanc.
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ABSTRACT
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Links
