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PDBsum entry 4cdc
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Contents |
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114 a.a.
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162 a.a.
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68 a.a.
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References listed in PDB file
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Key reference
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Title
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Cathepsin c inhibitors: property optimization and identification of a clinical candidate.
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Authors
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M.Furber,
A.K.Tiden,
P.Gardiner,
A.Mete,
R.Ford,
I.Millichip,
L.Stein,
A.Mather,
E.Kinchin,
C.Luckhurst,
S.Barber,
P.Cage,
H.Sanganee,
R.Austin,
K.Chohan,
R.Beri,
B.Thong,
A.Wallace,
V.Oreffo,
R.Hutchinson,
S.Harper,
J.Debreczeni,
J.Breed,
L.Wissler,
K.Edman.
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Ref.
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J Med Chem, 2014,
57,
2357-2367.
[DOI no: ]
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PubMed id
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Abstract
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A lead generation and optimization program delivered the highly selective and
potent CatC inhibitor 10 as an in vivo tool compound and potential development
candidate. Structural studies were undertaken to generate SAR understanding.
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