PDBsum entry 4cct

Virus

PDB id: 4cct

Contents

Protein chains

495 a.a.*

74 a.a.*

* C-alpha coords only

References listed in PDB file

Key reference

• Title: Immature and mature dengue serotype 1 virus structures provide insight into the maturation process.
• Authors: V.A.Kostyuchenko, Q.Zhang, J.L.Tan, T.S.Ng, S.M.Lok.
• Ref.: J Virol, 2013, 87, 7700-7707. [DOI no: 10.1128/JVI.00197-13]
• PubMed id: 23637416

Abstract

Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-Å resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation.