UniProt functional annotation for Q5M7L6



	UniProt functional annotation for Q5M7L6

UniProt code: Q5M7L6.

Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.

Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720). {ECO:0000250|UniProtKB:Q5UE90, ECO:0000250|UniProtKB:Q6UXX9, ECO:0000269|PubMed:29769720}.

Subunit: Binds heparin. {ECO:0000250|UniProtKB:Q8BFU0}.

Subcellular location: Secreted {ECO:0000250|UniProtKB:Q5UE90}.

Domain: The FU repeat is required for activation and stabilization of beta-catenin. {ECO:0000250}.

Disruption phenotype: Mutant animals exhibit marked forelimb and hindlimb amelia. {ECO:0000269|PubMed:29769720}.

Similarity: Belongs to the R-spondin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.



Function:		Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720). {ECO:0000250\|UniProtKB:Q5UE90, ECO:0000250\|UniProtKB:Q6UXX9, ECO:0000269\|PubMed:29769720}.


Subunit:		Binds heparin. {ECO:0000250\|UniProtKB:Q8BFU0}.
Subcellular location:		Secreted {ECO:0000250\|UniProtKB:Q5UE90}.
Domain:		The FU repeat is required for activation and stabilization of beta-catenin. {ECO:0000250}.
Disruption phenotype:		Mutant animals exhibit marked forelimb and hindlimb amelia. {ECO:0000269\|PubMed:29769720}.
Similarity:		Belongs to the R-spondin family. {ECO:0000305}.