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UniProt functional annotation for Q08D68 | ||
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| UniProt code: Q08D68. |
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| Organism: | |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana. |
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| Function: | |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (PubMed:29769720). {ECO:0000250|UniProtKB:Q9ULT6, ECO:0000269|PubMed:29769720}. |
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| Catalytic activity: | |
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; |
| Pathway: | |
Protein modification; protein ubiquitination. |
| Subcellular location: | |
Cell membrane {ECO:0000250|UniProtKB:Q9ULT6}; Single-pass type I membrane protein {ECO:0000255}. |
| Disruption phenotype: | |
Simultaneous knockdown of RNF43 and ZNRF3 results in ectopic limb development. {ECO:0000269|PubMed:29769720}. |
| Similarity: | |
Belongs to the ZNRF3 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.