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PDBsum entry 4c56
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Immune system/toxin
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PDB id
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4c56
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Contents |
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192 a.a.
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240 a.a.
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227 a.a.
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178 a.a.
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184 a.a.
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13 a.a.
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198 a.a.
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References listed in PDB file
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Key reference
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Title
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Structure of the superantigen staphylococcal enterotoxin b in complex with tcr and peptide-Mhc demonstrates absence of tcr-Peptide contacts.
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Authors
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K.E.Rödström,
K.Elbing,
K.Lindkvist-Petersson.
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Ref.
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J Immunol, 2014,
193,
1998-2004.
[DOI no: ]
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PubMed id
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Abstract
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Superantigens are immune-stimulatory toxins produced by Staphylococcus aureus,
which are able to interact with host immune receptors to induce a massive
release of cytokines, causing toxic shock syndrome and possibly death. In this
article, we present the x-ray structure of staphylococcal enterotoxin B (SEB) in
complex with its receptors, the TCR and MHC class II, forming a ternary complex.
The structure, in combination with functional analyses, clearly shows how SEB
adopts a wedge-like position when binding to the β-chain of TCR, allowing for
an interaction between the α-chain of TCR and MHC. Furthermore, the binding
mode also circumvents contact between TCR and the peptide presented by MHC,
which enables SEB to initiate a peptide-independent activation of T cells.
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