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PDBsum entry 4c3z
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Transport protein
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PDB id
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4c3z
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PDB id:
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| Name: |
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Transport protein
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Title:
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Nucleotide-free crystal structure of nucleotide-binding domain 1 from human mrp1 supports a general-base catalysis mechanism for atp hydrolysis.
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Structure:
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Multidrug resistance-associated protein 1. Chain: a. Fragment: nucleotide binding domain, residues 628-881. Synonym: atp-binding cassette sub-family c member 1, leukotrienE C(4) transporter, ltc4 transporter, nucleotide binding domain 1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.10Å
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R-factor:
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0.165
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R-free:
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0.194
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Authors:
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V.Chaptal,V.Gueguen-Chaignon,S.Magnard,P.Falson,A.Di Pietro, H.Baubichon-Cortay
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Key ref:
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V.Chaptal
et al.
Nucleotide-Free crystal structure of nucleotide- Bind domain 1 from human mrp1 supports a general-Base cata mechanism for ATP hydrolysis.
To be published,
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Date:
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28-Aug-13
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Release date:
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10-Sep-14
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PROCHECK
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Headers
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References
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P33527
(MRP1_HUMAN) -
Multidrug resistance-associated protein 1 from Homo sapiens
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Seq:
Struc:
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1531 a.a.
231 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class 2:
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E.C.7.6.2.2
- ABC-type xenobiotic transporter.
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Reaction:
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ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2
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ATP
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+
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H2O
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+
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xenobioticSide 1
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=
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ADP
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+
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phosphate
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+
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xenobioticSide 2
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Enzyme class 3:
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E.C.7.6.2.3
- ABC-type glutathione-S-conjugate transporter.
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Reaction:
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an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H+
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S-substituted glutathione(in)
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+
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ATP
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+
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H2O
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=
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S-substituted glutathione(out)
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+
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ADP
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+
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phosphate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
