UniProt functional annotation for Q8IMX7



	UniProt functional annotation for Q8IMX7

UniProt code: Q8IMX7.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16055062, PubMed:16717129, PubMed:22396657). Forms an essential protein complex with Milt that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria (PubMed:16717129). Required for axonal transport to synapses within nerve terminals (PubMed:16055062, PubMed:22396657). Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs) (PubMed:16055062). {ECO:0000269|PubMed:16055062, ECO:0000269|PubMed:16717129, ECO:0000269|PubMed:22396657}.

Subunit: Interacts with kinesin-associated protein milt. {ECO:0000269|PubMed:14605208, ECO:0000269|PubMed:16717129}.

Subcellular location: Mitochondrion outer membrane {ECO:0000305|PubMed:16055062}; Single-pass type IV membrane protein {ECO:0000305|PubMed:16055062}.

Disruption phenotype: Flies die at early pupal stage and exhibit abnormal locomotion (PubMed:16055062). Mitochondria in muscles and neurons are abnormally distributed (PubMed:16055062). Instead of being transported into axons and dendrites, mitochondria accumulate in parallel rows in neuronal somata (PubMed:16055062). Mutant NMJs lack presynaptic mitochondria, but neurotransmitter release and acute Ca(2+) buffering is only impaired during prolonged stimulation (PubMed:16055062). RNAi-mediated knockdown in the dopaminergic (DA) neurons decreases mitochondrial length and mitochondrial flux, and mitochondria accumulate in the most distal boutons of the DA motor neuron nerve terminals (PubMed:22396657). {ECO:0000269|PubMed:16055062, ECO:0000269|PubMed:22396657}.

Similarity: Belongs to the mitochondrial Rho GTPase family. {ECO:0000255|PROSITE-ProRule:PRU00757, ECO:0000305}.

Sequence caution: Sequence=AAL13784.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16055062, PubMed:16717129, PubMed:22396657). Forms an essential protein complex with Milt that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria (PubMed:16717129). Required for axonal transport to synapses within nerve terminals (PubMed:16055062, PubMed:22396657). Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs) (PubMed:16055062). {ECO:0000269\|PubMed:16055062, ECO:0000269\|PubMed:16717129, ECO:0000269\|PubMed:22396657}.


Subunit:		Interacts with kinesin-associated protein milt. {ECO:0000269\|PubMed:14605208, ECO:0000269\|PubMed:16717129}.
Subcellular location:		Mitochondrion outer membrane {ECO:0000305\|PubMed:16055062}; Single-pass type IV membrane protein {ECO:0000305\|PubMed:16055062}.
Disruption phenotype:		Flies die at early pupal stage and exhibit abnormal locomotion (PubMed:16055062). Mitochondria in muscles and neurons are abnormally distributed (PubMed:16055062). Instead of being transported into axons and dendrites, mitochondria accumulate in parallel rows in neuronal somata (PubMed:16055062). Mutant NMJs lack presynaptic mitochondria, but neurotransmitter release and acute Ca(2+) buffering is only impaired during prolonged stimulation (PubMed:16055062). RNAi-mediated knockdown in the dopaminergic (DA) neurons decreases mitochondrial length and mitochondrial flux, and mitochondria accumulate in the most distal boutons of the DA motor neuron nerve terminals (PubMed:22396657). {ECO:0000269\|PubMed:16055062, ECO:0000269\|PubMed:22396657}.
Similarity:		Belongs to the mitochondrial Rho GTPase family. {ECO:0000255\|PROSITE-ProRule:PRU00757, ECO:0000305}.
Sequence caution:		Sequence=AAL13784.1; Type=Erroneous initiation; Evidence={ECO:0000305};