PDBsum entry 4bzd

Transferase

PDB id: 4bzd

Contents

Protein chain

277 a.a.

Ligands

ACT

D6I

Waters ×215

PDB id:

4bzd

Name:

Transferase

Title:

Structure of cdk2 in complex with a benzimidazopyrimidine

Structure:

Cyclin-dependent kinase 2. Chain: a. Synonym: cell division protein kinase 2, p33 protein kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Resolution:

1.83Å R-factor: 0.175 R-free: 0.204

Authors:

J.A.Tucker,A.Valentine,J.Stanway,C.Brassington

Key ref:

C.Rye Structure of cdk2 in complex with a benzimidazopyrimi. To be published, .

Date:

25-Jul-13 Release date: 13-Aug-14

Protein chain

P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2 from Homo sapiens

Seq: 298 a.a.

Struc: 277 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.22 - cyclin-dependent kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site