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PDBsum entry 4bl1
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PDB id:
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Transferase
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Title:
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Crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex with amp-pnp
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Structure:
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Maternal embryonic leucine zipper kinase. Chain: a. Fragment: kinase and uba domains, residues 2-340. Synonym: hmelk, protein kinase eg3, peg3 kinase, protein kinase pk38, hpk38, tyrosine-protein kinase melk. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
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Resolution:
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2.60Å
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R-factor:
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0.184
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R-free:
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0.260
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Authors:
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G.Canevari,S.Re-Depaolini,U.Cucchi,B.Forte,P.Carpinelli,J.A.Bertrand
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Key ref:
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G.Canevari
et al.
Crystal structure of unphosphorylated maternal embry leucine zipper kinase.
To be published,
.
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Date:
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30-Apr-13
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Release date:
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08-May-13
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Supersedes:
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PROCHECK
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Headers
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References
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Q14680
(MELK_HUMAN) -
Maternal embryonic leucine zipper kinase from Homo sapiens
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Seq:
Struc:
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651 a.a.
312 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class 2:
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E.C.2.7.10.2
- non-specific protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
Bound ligand (Het Group name = )
matches with 81.25% similarity
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+
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ADP
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+
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H(+)
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Enzyme class 3:
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E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
Bound ligand (Het Group name = )
matches with 81.25% similarity
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
Bound ligand (Het Group name = )
matches with 81.25% similarity
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+
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ADP
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
