UniProt functional annotation for P22001



	UniProt functional annotation for P22001

UniProt code: P22001.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein.

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Ptm: N-glycosylation promotes the cell surface expression. {ECO:0000250}.

Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAA36425.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA36425.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAB88073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.


Subunit:		Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity). {ECO:0000250}.
Subcellular location:		Cell membrane {ECO:0000250}; Multi-pass membrane protein.
Domain:		The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
Domain:		The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Ptm:		N-glycosylation promotes the cell surface expression. {ECO:0000250}.
Similarity:		Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAA36425.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA36425.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAB88073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Frameshift; Evidence={ECO:0000305};