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UniProt functional annotation for Q9ES57 | ||
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| UniProt code: Q9ES57. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. {ECO:0000269|PubMed:12960329, ECO:0000269|PubMed:15187158}. |
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| Subunit: | |
CD200 and CD200R1 interact via their respective N-terminal Ig- like domains. {ECO:0000269|PubMed:23602662}. |
| Subcellular location: | |
Cell membrane; Single-pass type I membrane protein. |
| Tissue specificity: | |
Expressed in granulocytes, monocytes, most T-cells and a subset of NK, NKT and B-cells (at protein level). Expressed in the spleen, lung, liver, testis, bone marrow, lymph nodes, spinal cord, kidney, uterus and small intestine. Expressed in mast and dendritic cells. Expressed in the lung of N. brasiliensis-infected mice. {ECO:0000269|PubMed:12960329, ECO:0000269|PubMed:15187158, ECO:0000269|PubMed:15274657, ECO:0000269|PubMed:15471863}. |
| Similarity: | |
Belongs to the CD200R family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.