PDBsum entry 4bdx

Hydrolase

PDB id: 4bdx

Contents

Protein chain

83 a.a.

Ligands

ACT

Waters ×67

PDB id:

4bdx

Name:

Hydrolase

Title:

The structure of the fni-egf tandem domain of coagulation factor xii

Structure:

Coagulation factor xiia heavy chain. Chain: a. Fragment: fni-egf, residues 133-215. Synonym: coagulation factor xii, hageman factor, haf. Engineered: yes

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922.

Resolution:

1.62Å R-factor: 0.217 R-free: 0.247

Authors:

D.X.Beringer,L.M.J.Kroon-Batenburg

Key ref:

D.X.Beringer and L.M.Kroon-Batenburg (2013). The structure of the FnI-EGF-like tandem domain of coagulation factor XII solved using SIRAS. Acta Crystallogr Sect F Struct Biol Cryst Commun, 69, 94. PubMed id: 23385745 DOI: 10.1107/S1744309113000286

Date:

08-Oct-12 Release date: 13-Feb-13

Protein chain

P00748  (FA12_HUMAN) -  Coagulation factor XII from Homo sapiens

Seq: 615 a.a.

Struc: 83 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.38 - coagulation factor XIIa.
• Reaction: Cleaves selectively Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.

DOI no: 10.1107/S1744309113000286

Acta Crystallogr Sect F Struct Biol Cryst Commun 69:94 (2013)

PubMed id: 23385745

The structure of the FnI-EGF-like tandem domain of coagulation factor XII solved using SIRAS.

D.X.Beringer, L.M.Kroon-Batenburg.

ABSTRACT

No abstract given.