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UniProt functional annotation for P39008 | ||
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| UniProt code: P39008. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Acts as probably catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. In vitro, POP2 has 3'-exoribonuclease activity with a preference for poly(A) RNAs, but also degrades poly(U) and poly(C) RNAs. Is part of a glucose-sensing system involved in growth control in response to glucose availability. {ECO:0000269|PubMed:11239395, ECO:0000269|PubMed:11410650, ECO:0000269|PubMed:14618157, ECO:0000269|PubMed:9463387}. |
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| Catalytic activity: | |
Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Divalent metal cations. Mg(2+) is the most probable.; |
| Subunit: | |
Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex. {ECO:0000269|PubMed:10490603, ECO:0000269|PubMed:11733989, ECO:0000269|PubMed:14618157, ECO:0000269|PubMed:9463387}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:11239395}. Nucleus {ECO:0000269|PubMed:11239395}. |
| Miscellaneous: | |
Present with 1520 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the CAF1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.