PDBsum entry 4b2q

Hydrolase

PDB id: 4b2q

Contents

Protein chains

(+ 0 more) 485 a.a.

(+ 0 more) 470 a.a.

269 a.a.

132 a.a.

59 a.a.

(+ 14 more) 76 a.a.

129 a.a.

120 a.a.

65 a.a.

110 a.a.

Ligands

ATP ×6

ADP ×4

Metals

_MG ×10

PDB id:

4b2q

Name:

Hydrolase

Title:

Model of the yeast f1fo-atp synthase dimer based on subtomogram average

Structure:

Atp synthase subunit alpha, mitochondrial. Chain: a, c, a, c. Fragment: residues 61-545. Atp synthase subunit alpha, mitochondrial. Chain: b, b. Fragment: residues 60-545. Atp synthase subunit beta, mitochondrial. Chain: d, d. Fragment: residues 39-508.

Source:

Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: d273-10b/a. Organ: mitochondria. Bos taurus. Cattle. Organism_taxid: 9913. Organ: mitochondria

Authors:

K.M.Davies,W.Kuehlbrandt

Key ref:

K.M.Davies et al. (2012). Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae. Proc Natl Acad Sci U S A, 109, 13602-13607. PubMed id: 22864911

Date:

17-Jul-12 Release date: 29-Aug-12

Protein chains

P07251  (ATPA_YEAST) -  ATP synthase subunit alpha, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 545 a.a.

Struc: 485 a.a.

Protein chains

P00830  (ATPB_YEAST) -  ATP synthase subunit beta, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 511 a.a.

Struc: 470 a.a.

Protein chains

P38077  (ATPG_YEAST) -  ATP synthase subunit gamma, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 311 a.a.

Struc: 269 a.a.

Protein chains

Q12165  (ATPD_YEAST) -  ATP synthase subunit delta, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 160 a.a.

Struc: 132 a.a.

Protein chains

P21306  (ATP5E_YEAST) -  ATP synthase subunit epsilon, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 62 a.a.

Struc: 59 a.a.

Protein chains

P61829  (ATP9_YEAST) -  ATP synthase subunit 9, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 76 a.a.

Struc: 76 a.a.

Protein chains

P13619  (AT5F1_BOVIN) -  ATP synthase F(0) complex subunit B1, mitochondrial from Bos taurus

Seq: 256 a.a.

Struc: 129 a.a.

Protein chains

P13620  (ATP5H_BOVIN) -  ATP synthase subunit d, mitochondrial from Bos taurus

Seq: 161 a.a.

Struc: 120 a.a.

Protein chains

P02721  (ATP5J_BOVIN) -  ATP synthase-coupling factor 6, mitochondrial from Bos taurus

Seq: 108 a.a.

Struc: 65 a.a.

Protein chains

P13621  (ATPO_BOVIN) -  ATP synthase subunit O, mitochondrial from Bos taurus

Seq: 213 a.a.

Struc: 110 a.a.

Enzyme reactions

• Enzyme class 2: Chains A, B, C, G, H, I, J, K, L, M, N, O, P, Q, R, S, U, V, a, b, c, g, h, i, j, k, l, m, n, o, p, q, r, s, u, v: E.C.?
• Enzyme class 3: Chains D, E, F, d, e, f: E.C.7.1.2.2 - H(+)-transporting two-sector ATPase.
• Reaction: ATP + H2O + 4 H⁺(in) = ADP + phosphate + 5 H⁺(out)

ATP (Bound ligand (Het Group name = ATP) corresponds exactly) + H2O + 4 × H(+)(in) = ADP + phosphate + 5 × H(+)(out)

• Enzyme class 4: Chains T, W, t, w: E.C.3.6.3.14 - Transferred entry: 7.1.2.2.
• Reaction: ATP + H₂O + H⁺(In) = ADP + phosphate + H⁺(Out)

ATP + H(2)O + 4 × H(+)(In) = ADP (Bound ligand (Het Group name = ATP) matches with 87.10% similarity) + phosphate + 5 × H(+)(Out)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Proc Natl Acad Sci U S A 109:13602-13607 (2012)

PubMed id: 22864911

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae.

K.M.Davies, C.Anselmi, I.Wittig, J.D.Faraldo-Gómez, W.Kühlbrandt.

ABSTRACT

No abstract given.