|
|
||
|
|
|
|
|
UniProt functional annotation for P01215 | ||
|
|
|
|
|
|
||
| UniProt code: P01215. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. {ECO:0000269|PubMed:24692546, ECO:0000269|PubMed:2494176}. |
|
||
| Subunit: | |
Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin. {ECO:0000269|PubMed:15662415, ECO:0000269|PubMed:2494176}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:24692546, ECO:0000269|PubMed:2494176}. |
| Similarity: | |
Belongs to the glycoprotein hormones subunit alpha family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.