PDBsum entry 4ay9

Hormone/receptor

PDB id: 4ay9

Contents

Protein chains

88 a.a.

107 a.a.

307 a.a.

Ligands

NAG ×15

Waters ×223

PDB id:

4ay9

Name:

Hormone/receptor

Title:

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

Structure:

Glycoprotein hormones, alpha polypeptide. Chain: a, d, g. Fragment: residues 25-116. Engineered: yes. Follitropin subunit beta. Chain: b, e, h. Synonym: follicle-stimulating hormone beta subunit, fsh-b, fsh-beta, follitropin beta chain. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Other_details: bacman system. Other_details: bacman system

Resolution:

2.50Å R-factor: 0.237 R-free: 0.269

Authors:

X.Jiang,H.Liu,X.Chen,X.He

Key ref:

X.Jiang et al. (2012). Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor. Proc Natl Acad Sci U S A, 109, 12491-12496. PubMed id: 22802634

Date:

19-Jun-12 Release date: 08-Aug-12

Protein chains

P01215  (GLHA_HUMAN) -  Glycoprotein hormones alpha chain from Homo sapiens

Seq: 116 a.a.

Struc: 88 a.a.*

Protein chains

P01225  (FSHB_HUMAN) -  Follitropin subunit beta from Homo sapiens

Seq: 129 a.a.

Struc: 107 a.a.

Protein chains

P23945  (FSHR_HUMAN) -  Follicle-stimulating hormone receptor from Homo sapiens

Seq: 695 a.a.

Struc: 307 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Proc Natl Acad Sci U S A 109:12491-12496 (2012)

PubMed id: 22802634

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor.

X.Jiang, H.Liu, X.Chen, P.H.Chen, D.Fischer, V.Sriraman, H.N.Yu, S.Arkinstall, X.He.

ABSTRACT

No abstract given.