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UniProt functional annotation for Q15750 | ||
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| UniProt code: Q15750. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. |
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| Subunit: | |
Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167). {ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11323434, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:11865055, ECO:0000269|PubMed:17560374, ECO:0000269|PubMed:8638164}. |
| Tissue specificity: | |
Ubiquitous. |
| Ptm: | |
Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP. |
| Miscellaneous: | |
[Isoform 2]: Does not bind nor activate MAP3K7/TAK1. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.