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UniProt functional annotation for O05581 | ||
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| UniProt code: O05581. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes. {ECO:0000269|PubMed:20507997, ECO:0000269|PubMed:21627103, ECO:0000269|PubMed:22773105}. |
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| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:22773105}; |
| Activity regulation: | |
Autoinhibited and allosterically activated by 3,5- cyclic adenosine monophosphate (cAMP). An extensive conformational rearrangement relieves this autoinhibition by means of a substrate- mimicking lid that covers the protein-substrate binding surface. {ECO:0000269|PubMed:21627103, ECO:0000269|PubMed:22773105}. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:22773105}. |
Annotations taken from UniProtKB at the EBI.