PDBsum entry 4arr

Immune system

PDB id: 4arr

Contents

Protein chains

272 a.a.

Ligands

NAG ×3

I3C ×2

PDB id:

4arr

Name:

Immune system

Title:

Crystal structure of the n-terminal domain of drosophila toll receptor with the magic triangle i3c

Structure:

Toll receptor, variable lymphocyte receptor b.61 chimera. Chain: a, b. Fragment: toll receptor (unp residues 28-228), variable lymphocyte receptor b.61 (unp residues 133-201). Synonym: toll, variable lymphocyte receptor b. Engineered: yes. Other_details: chimeric protein

Source:

Drosophila melanogaster, eptatretus burgeri. Fruit fly, inshore hagfish. Organism_taxid: 7227, 7764. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

3.00Å R-factor: 0.226 R-free: 0.254

Authors:

M.Gangloff,N.J.Gay

Key ref:

M.Gangloff et al. (2013). Liesegang-like patterns of Toll crystals grown in gel. J Appl Crystallogr, 46, 337-345. PubMed id: 23596340 DOI: 10.1107/S0021889812051606

Date:

26-Apr-12 Release date: 27-Feb-13

Protein chains

P08953  (TOLL_DROME) -  Protein toll from Drosophila melanogaster

Seq: 1097 a.a.

Struc: 272 a.a.*

Protein chains

Q4G1L2  (Q4G1L2_EPTBU) -  Variable lymphocyte receptor B from Eptatretus burgeri

Seq: 273 a.a.

Struc: 272 a.a.*

* PDB and UniProt seqs differ at 165 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.2.2.6 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
• Reaction: NAD⁺ + H2O = ADP-D-ribose + nicotinamide + H⁺

NAD(+) + H2O = ADP-D-ribose + nicotinamide (Bound ligand (Het Group name = NAG) matches with 43.75% similarity) + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1107/S0021889812051606

J Appl Crystallogr 46:337-345 (2013)

PubMed id: 23596340

Liesegang-like patterns of Toll crystals grown in gel.

M.Gangloff, A.Moreno, N.J.Gay.

ABSTRACT

No abstract given.