PDBsum entry 4ap7

Transferase

PDB id: 4ap7

Contents

Protein chain

290 a.a.

Ligands

F47

Waters ×299

References listed in PDB file

Key reference

• Title: Discovery of a novel class of exquisitely selective mesenchymal-Epithelial transition factor (c-Met) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(Quinolin-6-Ylmethyl)-1h-[1,2,3]triazolo[4,5-B]pyrazin-6-Yl)-1h-Pyrazol-1-Yl)ethanol (pf-04217903) for the treatment of cancer.
• Authors: J.J.Cui, M.Mctigue, M.Nambu, M.Tran-Dubé, M.Pairish, H.Shen, L.Jia, H.Cheng, J.Hoffman, P.Le, M.Jalaie, G.H.Goetz, K.Ryan, N.Grodsky, Y.L.Deng, M.Parker, S.Timofeevski, B.W.Murray, S.Yamazaki, S.Aguirre, Q.Li, H.Zou, J.Christensen.
• Ref.: J Med Chem, 2012, 55, 8091-8109.
• PubMed id: 22924734

Abstract

No abstract given.