PDBsum entry 4ans

Transferase

PDB id: 4ans

Contents

Protein chain

294 a.a.

Ligands

VGH

Waters ×210

PDB id:

4ans

Name:

Transferase

Title:

Structure of l1196m,g1269a double mutant anaplastic lymphoma kinase in complex with crizotinib

Structure:

Alk tyrosine kinase receptor. Chain: a. Fragment: kinase, residues 1093-1411. Synonym: anaplastic lymphoma kinase, cd246. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

1.85Å R-factor: 0.201 R-free: 0.231

Authors:

M.Mctigue,Y.Deng,W.Liu,A.Brooun

Key ref:

M.Mctigue et al. Structure of l1196m,G1269a double mutant anaplastic lymphoma kinase in complex with crizotinib. To be published, .

Date:

22-Mar-12 Release date: 27-Mar-13

Protein chain

Q9UM73  (ALK_HUMAN) -  ALK tyrosine kinase receptor from Homo sapiens

Seq: 1620 a.a.

Struc: 294 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site