PDBsum entry 4anm

Transferase

PDB id

4anm

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Contents

			Protein chain

					328 a.a.

			Ligands

					WUL

			Waters ×356

PDB id:

4anm

Links

Name:

Transferase

Title:

Complex of ck2 with a cdc7 inhibitor

Structure:

Casein kinase ii subunit alpha. Chain: a. Fragment: kinase domain, residues 2-332. Synonym: ck ii, ck2-alpha, ck2. Engineered: yes

Source:

Zea mays. Maize. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.70Å

R-factor:

0.166

R-free:

0.202

Authors:

T.J.Stout

Key ref:

E.S.Koltun et al. (2012). Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett, 22, 3727-3731. PubMed id: 22560567

Date:

20-Mar-12

Release date:

23-May-12

PROCHECK

	Headers

	References

Protein chain

P28523 (CSK2A_MAIZE) - Casein kinase II subunit alpha from Zea mays

Seq: Struc:					332 a.a. 328 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 1 residue position (black cross)



		Enzyme reactions

Enzyme class:

E.C.2.7.11.1 - non-specific serine/threonine protein kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

1.	L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
2.	L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

L-seryl-[protein]	+	ATP	=	O-phospho-L-seryl-[protein]	+	ADP	+	H(+)

L-threonyl-[protein]	+	ATP	=	O-phospho-L-threonyl-[protein]	+	ADP	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

	Bioorg Med Chem Lett 22:3727-3731 (2012)
PubMed id: 22560567

Discovery of XL413, a potent and selective CDC7 inhibitor.
E.S.Koltun, A.L.Tsuhako, D.S.Brown, N.Aay, A.Arcalas, V.Chan, H.Du, S.Engst, K.Ferguson, M.Franzini, A.Galan, C.R.Holst, P.Huang, B.Kane, M.H.Kim, J.Li, D.Markby, M.Mohan, K.Noson, A.Plonowski, S.J.Richards, S.Robertson, K.Shaw, G.Stott, T.J.Stout, J.Young, P.Yu, C.A.Zaharia, W.Zhang, P.Zhou, J.M.Nuss, W.Xu, P.C.Kearney.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23064647

S.Hughes, F.Elustondo, A.Di Fonzo, F.G.Leroux, A.C.Wong, A.P.Snijders, S.J.Matthews, and P.Cherepanov (2012).
Crystal structure of human CDC7 kinase in complex with its activator DBF4.

Nat Struct Mol Biol, 19, 1101-1107.

PDB codes:

4f99 4f9a 4f9b 4f9c

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.