PDBsum entry 4akh

Motor protein

PDB id: 4akh

Contents

Protein chains

2650 a.a.

Ligands

ATP ×2

ANP ×2

SO4 ×4

Metals

_MG ×2

PDB id:

4akh

Name:

Motor protein

Title:

Dynein motor domain - amppnp complex

Structure:

Glutathione s-transferase class-mu 26 kda isozyme, dynein heavy chain cytoplasmic. Chain: a, b. Fragment: residues 1-218,1364-3038,3292-4092. Synonym: gst 26, sj26 antigen, sjgst, dyhc. Engineered: yes

Source:

Schistosoma japonicum, saccharomyces cerevisiae. Organism_taxid: 6182, 4932. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932

Resolution:

3.60Å R-factor: 0.244 R-free: 0.302

Authors:

H.Schmidt,E.S.Gleave,A.P.Carter

Key ref:

H.Schmidt et al. (2012). Insights into dynein motor domain function from a 3.3-Å crystal structure. Nat Struct Biol, 19, 492. PubMed id: 22426545

Date:

22-Feb-12 Release date: 14-Mar-12

Protein chains

P08515  (GST26_SCHJA) -  Glutathione S-transferase class-mu 26 kDa isozyme from Schistosoma japonicum

Seq: 218 a.a.

Struc: 2650 a.a.*

Protein chains

P36022  (DYHC_YEAST) -  Dynein heavy chain, cytoplasmic from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 4092 a.a.

Struc: 2650 a.a.*

* PDB and UniProt seqs differ at 204 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.5.1.18 - glutathione transferase.
• Reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Nat Struct Biol 19:492 (2012)

PubMed id: 22426545

Insights into dynein motor domain function from a 3.3-Å crystal structure.

H.Schmidt, E.S.Gleave, A.P.Carter.

ABSTRACT

No abstract given.