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UniProt functional annotation for P08515 | ||
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| UniProt code: P08515. |
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| Organism: | |
Schistosoma japonicum (Blood fluke). |
| Taxonomy: | |
Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda; Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma. |
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| Function: | |
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. |
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| Function: | |
GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. |
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| Catalytic activity: | |
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:7853399}. |
| Miscellaneous: | |
There are at least two isoenzymes of GST in S.japonicum. |
| Similarity: | |
Belongs to the GST superfamily. Mu family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.