PDBsum entry 4ag2

Hydrolase/de novo protein

PDB id: 4ag2

Contents

Protein chains

223 a.a.

58 a.a.

Ligands

MES ×2

LMR ×3

Metals

_NA ×5

Waters ×514

PDB id:

4ag2

Name:

Hydrolase/de novo protein

Title:

Human chymase - fynomer complex

Structure:

Chymase. Chain: a, b. Synonym: alpha-chymase, mast cell protease i. Engineered: yes. Fynomer. Chain: c, d. Engineered: yes

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic construct. Organism_taxid: 32630. Expression_system_taxid: 562

Resolution:

1.80Å R-factor: 0.180 R-free: 0.212

Authors:

D.Schlatter,S.Brack,D.W.Banner,S.Batey,J.Benz,J.Bertschinger,W.Huber, C.Joseph,A.Rufer,A.Van Der Kloosters,M.Weber,D.Grabulovski,M.Hennig

Key ref:

D.Schlatter et al. (2012). Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain. Mabs, 4, 497-508. PubMed id: 22653218

Date:

23-Jan-12 Release date: 11-Jul-12

Protein chains

P23946  (CMA1_HUMAN) -  Chymase from Homo sapiens

Seq: 247 a.a.

Struc: 223 a.a.

Protein chains

No UniProt id for this chain

Struc: 58 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.21.39 - chymase.
• Reaction: Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.

Mabs 4:497-508 (2012)

PubMed id: 22653218

Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain.

D.Schlatter, S.Brack, D.W.Banner, S.Batey, J.Benz, J.Bertschinger, W.Huber, C.Joseph, A.Rufer, A.van der Klooster, M.Weber, D.Grabulovski, M.Hennig.

ABSTRACT

No abstract given.