PDBsum entry 4ag1

Hydrolase/de novo protein

PDB id: 4ag1

Contents

Protein chains

221 a.a.

63 a.a.

Ligands

SO4

Waters ×273

PDB id:

4ag1

Name:

Hydrolase/de novo protein

Title:

Human chymase - fynomer complex

Structure:

Chymase. Chain: a. Synonym: alpha-chymase, mast cell protease i. Engineered: yes. Fynomer. Chain: c. Engineered: yes

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic construct. Organism_taxid: 32630. Expression_system_taxid: 562

Resolution:

1.40Å R-factor: 0.140 R-free: 0.170

Authors:

D.Schlatter,S.Brack,D.W.Banner,S.Batey,J.Benz,J.Bertschinger,W.Huber, C.Joseph,A.Rufer,A.Van Der Kloosters,M.Weber,D.Grabulovski,M.Hennig

Key ref:

D.Schlatter et al. (2012). Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain. Mabs, 4, 497-508. PubMed id: 22653218

Date:

23-Jan-12 Release date: 11-Jul-12

Protein chain

P23946  (CMA1_HUMAN) -  Chymase from Homo sapiens

Seq: 247 a.a.

Struc: 221 a.a.

Protein chain

No UniProt id for this chain

Struc: 63 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.3.4.21.39 - chymase.
• Reaction: Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.

Mabs 4:497-508 (2012)

PubMed id: 22653218

Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain.

D.Schlatter, S.Brack, D.W.Banner, S.Batey, J.Benz, J.Bertschinger, W.Huber, C.Joseph, A.Rufer, A.van der Klooster, M.Weber, D.Grabulovski, M.Hennig.

ABSTRACT

No abstract given.