PDBsum entry 4ae3

Hydrolase

PDB id: 4ae3

Contents

Protein chain

743 a.a.

Ligands

AOV

27X ×2

EDO ×4

Metals

_MG

Waters ×439

PDB id:

4ae3

Name:

Hydrolase

Title:

Crystal structure of ammosamide 272:myosin-2 motor domain complex

Structure:

Myosin-2 heavy chain. Chain: a. Fragment: motor domain, residues 2-761. Synonym: myosin ii heavy chain. Engineered: yes

Source:

Dictyostelium discoideum. Organism_taxid: 352472. Strain: ax4. Expressed in: dictyostelium discoideum. Expression_system_taxid: 352472.

Resolution:

2.50Å R-factor: 0.216 R-free: 0.254

Authors:

K.Chinthalapudi,S.M.Heissler,W.Fenical,D.J.Manstein

Key ref:

K.Chinthalapudi et al. Structural basis for ammosamide mediated myosin motor activity inhibition. To be published, .

Date:

05-Jan-12 Release date: 16-Jan-13

Protein chain

P08799  (MYS2_DICDI) -  Myosin-2 heavy chain from Dictyostelium discoideum

Seq: 2116 a.a.

Struc: 743 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.4.1 - Transferred entry: 5.6.1.8.
• Reaction: ATP + H₂O = ADP + phosphate

ATP + H(2)O = ADP (Bound ligand (Het Group name = AOV) matches with 84.38% similarity) + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site