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PDBsum entry 4aaa

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protein ligands links
Transferase PDB id
4aaa
Jmol PyMol
Contents
Protein chain
295 a.a.
Ligands
DKI
EDO ×6
Waters ×259
PDB id:
4aaa
Name: Transferase
Title: Crystal structure of the human cdkl2 kinase domain
Structure: Cyclin-dependent kinase-like 2. Chain: a. Fragment: kinase domain, residues 1-308. Synonym: protein kinase p56 kkiamre, serine/threonine-prote kinase kkiamre. Engineered: yes. Mutation: yes. Other_details: his85 conformation b and asp84 conformation not be occupied simultaneously.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Resolution:
1.53Å     R-factor:   0.181     R-free:   0.208
Authors: P.Canning,M.Vollmar,C.D.O.Cooper,P.Mahajan,N.Daga,G.Berridge N.Burgess-Brown,J.R.C.Muniz,T.Krojer,F.Von Delft,J.Weigelt, C.H.Arrowsmith,A.M.Edwards,C.Bountra,A.Bullock
Key ref: P.Canning and a.bullock Crystal structure of the human cdkl2 kinase domain. To be published, .
Date:
30-Nov-11     Release date:   21-Dec-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q92772  (CDKL2_HUMAN) -  Cyclin-dependent kinase-like 2
Seq:
Struc:
493 a.a.
295 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     protein kinase activity     2 terms  

 

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