PDBsum entry 4a9h

Signaling protein

PDB id: 4a9h

Contents

Protein chain

112 a.a.

Ligands

EDO ×2

TVP ×3

SO4 ×2

Waters ×320

PDB id:

4a9h

Name:

Signaling protein

Title:

N-terminal bromodomain of human brd2 with 1-(2-methyl-1,2,3,4- tetrahydroquinolin-1-yl)ethan-1-one

Structure:

Bromodomain-containing protein 2. Chain: a, b, c. Fragment: n-terminal bromodomain (bd1), residues 67-200. Synonym: human brd2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.05Å R-factor: 0.161 R-free: 0.205

Authors:

C.W.Chung,P.Bamborough

Key ref:

C.W.Chung et al. (2012). Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery. J Med Chem, 55, 576-586. PubMed id: 22136404

Date:

26-Nov-11 Release date: 11-Jan-12

Protein chains

P25440  (BRD2_HUMAN) -  Bromodomain-containing protein 2 from Homo sapiens

Seq: 801 a.a.

Struc: 112 a.a.

J Med Chem 55:576-586 (2012)

PubMed id: 22136404

Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery.

C.W.Chung, A.W.Dean, J.M.Woolven, P.Bamborough.

ABSTRACT

No abstract given.