PDBsum entry 4a82

Transport protein

PDB id: 4a82

Contents

Protein chains

578 a.a.

PDB id:

4a82

Name:

Transport protein

Title:

Fitted model of staphylococcus aureus sav1866 model abc transporter in the human cystic fibrosis transmembrane conductance regulator volume map emd-1966.

Structure:

Cystic fibrosis transmembrane conductance regulator. Chain: a, b, c, d. Other_details: human cftr protein is glycosylated but non- phosphorylated, as expressed and purified from bhk cells. No nucleotide is present during purification and crystallisation. The sav1866 model is a bacterial abc transporter, suspected to be a multidrug efflux transporter. It is in the outward-facing configuration. The original PDB id for the sav1866 model used is 2hyd.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Other_details: stably transfected bhk cells.

Authors:

M.F.Rosenberg,L.P.Oryan,G.Hughes,Z.Zhao,L.A.Aleksandrov,J.R.Riordan, R.C.Ford

Key ref:

M.F.Rosenberg et al. (2011). The cystic fibrosis transmembrane conductance regulator (CFTR): three-dimensional structure and localization of a channel gate. J Biol Chem, 286, 42647-42654. PubMed id: 21931164

Date:

18-Nov-11 Release date: 11-Jan-12

Protein chains

Q99T13  (Y1866_STAAM) -  Putative multidrug export ATP-binding/permease protein SAV1866 from Staphylococcus aureus (strain Mu50 / ATCC 700699)

Seq: 578 a.a.

Struc: 578 a.a.

Enzyme reactions

• Enzyme class: E.C.7.6.2.- - ?????

J Biol Chem 286:42647-42654 (2011)

PubMed id: 21931164

The cystic fibrosis transmembrane conductance regulator (CFTR): three-dimensional structure and localization of a channel gate.

M.F.Rosenberg, L.P.O'Ryan, G.Hughes, Z.Zhao, L.A.Aleksandrov, J.R.Riordan, R.C.Ford.

ABSTRACT

No abstract given.