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PDBsum entry 4a7l
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protein ligands metals Protein-protein interface(s) links
Structural protein/hydrolase PDB id
4a7l

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
375 a.a.
136 a.a.
689 a.a.
Ligands
ADP ×5
Metals
_CA ×5
PDB id:
4a7l
Name: Structural protein/hydrolase
Title: Structure of the actin-tropomyosin-myosin complex (rigor atm 1)
Structure: Actin, alpha skeleton muscle. Chain: a, d, e, f, i. Synonym: f-actin, alpha-actin-1. Tropomyosin 1 alpha. Chain: b, h. Fragment: residues 98-233. Engineered: yes. Myosin ie heavy chain. Chain: c, g, j.
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: skeletal muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Dictyostelium discoideum. Slime mold. Organism_taxid: 44689.
Authors: E.Behrmann,M.Mueller,P.A.Penczek,H.G.Mannherz,D.J.Manstein,S.Raunser
Key ref: E.Behrmann et al. (2012). Structure of the rigor actin-tropomyosin-myosin complex. Cell, 150, 327-338. PubMed id: 22817895
Date:
14-Nov-11     Release date:   01-Aug-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P68135  (ACTS_RABIT) -  Actin, alpha skeletal muscle from Oryctolagus cuniculus
Seq:
Struc: 		377 a.a.
375 a.a.*
Protein chains
Pfam   ArchSchema ?
P58772  (TPM1_RABIT) -  Tropomyosin alpha-1 chain from Oryctolagus cuniculus
Seq:
Struc: 		284 a.a.
136 a.a.
Protein chains
Pfam   ArchSchema ?
Q03479  (MYOE_DICDI) -  Myosin IE heavy chain from Dictyostelium discoideum
Seq:
Struc: 		 
Seq:
Struc: 		1005 a.a.
689 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 1: Chains A, D, E, F, I: E.C.3.6.4.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
   Enzyme class 2: Chains C, G, J: E.C.3.6.4.1  - Transferred entry: 5.6.1.8.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + H2O = ADP + phosphate
ATP
 + H(2)O
 =
ADP
Bound ligand (Het Group name = ADP)
corresponds exactly 		+ phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
Cell 150:327-338 (2012)
PubMed id: 22817895  
 
 
Structure of the rigor actin-tropomyosin-myosin complex.
E.Behrmann, M.Müller, P.A.Penczek, H.G.Mannherz, D.J.Manstein, S.Raunser.
 
  ABSTRACT  
 
No abstract given.

 

 

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