PDBsum entry 4a7c

Transferase

PDB id: 4a7c

Contents

Protein chain

274 a.a.

Ligands

E46

IMD

ACT

Waters ×190

PDB id:

4a7c

Name:

Transferase

Title:

Crystal structure of pim1 kinase with etp46546

Structure:

Proto-oncogene serine/threonine-protein kinase pim-1. Chain: a. Fragment: catalytic domain, residues 434-717. Synonym: pim1. Engineered: yes. Other_details: phosphorylated at ser 261

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss

Resolution:

2.30Å R-factor: 0.171 R-free: 0.207

Authors:

M.Mazzorana,G.Montoya

Key ref:

J.Pastor et al. (2012). Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors. Bioorg Med Chem Lett, 22, 1591-1597. PubMed id: 22266039

Date:

12-Nov-11 Release date: 15-Feb-12

Protein chain

P11309  (PIM1_HUMAN) -  Serine/threonine-protein kinase pim-1 from Homo sapiens

Seq: 313 a.a.

Struc: 274 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Bioorg Med Chem Lett 22:1591-1597 (2012)

PubMed id: 22266039

Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors.

J.Pastor, J.Oyarzabal, G.Saluste, R.M.Alvarez, V.Rivero, F.Ramos, E.Cendón, C.Blanco-Aparicio, N.Ajenjo, A.Cebriá, M.I.Albarrán, D.Cebrián, A.Corrionero, J.Fominaya, G.Montoya, M.Mazzorana.

ABSTRACT

No abstract given.