UniProt functional annotation for P40485



	UniProt functional annotation for P40485

UniProt code: P40485.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Together with SLM2, effector of the TORC2- and calcineurin- signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis. {ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:16738335, ECO:0000269|PubMed:16959779}.

Subunit: Heterodimer of SLM1-SLM2. Binds phosphatidylinositol 4,5- bisphosphate, which is required for function. Interacts with the TORC2 subunits AVO2, BIT61 and TOR2. Interacts with the calcineurin catalytic subunits CNA1 and CNA2. {ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:16738335, ECO:0000269|PubMed:16959779}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}; Peripheral membrane protein {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}; Cytoplasmic side {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}. Note=Localizes to cortical punctate structures. Correct localization requires phosphatidylinositol 4,5- bisphosphate and functional TORC2.

Ptm: Phosphorylated by the target of rapamycin complex 2 (TORC2) and dephosphorylated by serine/threonine-protein phosphatase 2B (calcineurin). {ECO:0000269|PubMed:15372071}.

Miscellaneous: Present with 5190 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Together with SLM2, effector of the TORC2- and calcineurin- signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis. {ECO:0000269\|PubMed:15372071, ECO:0000269\|PubMed:15689497, ECO:0000269\|PubMed:16738335, ECO:0000269\|PubMed:16959779}.


Subunit:		Heterodimer of SLM1-SLM2. Binds phosphatidylinositol 4,5- bisphosphate, which is required for function. Interacts with the TORC2 subunits AVO2, BIT61 and TOR2. Interacts with the calcineurin catalytic subunits CNA1 and CNA2. {ECO:0000269\|PubMed:15372071, ECO:0000269\|PubMed:15689497, ECO:0000269\|PubMed:16738335, ECO:0000269\|PubMed:16959779}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:15023338, ECO:0000269\|PubMed:15372071, ECO:0000269\|PubMed:15689497}; Peripheral membrane protein {ECO:0000269\|PubMed:15023338, ECO:0000269\|PubMed:15372071, ECO:0000269\|PubMed:15689497}; Cytoplasmic side {ECO:0000269\|PubMed:15023338, ECO:0000269\|PubMed:15372071, ECO:0000269\|PubMed:15689497}. Note=Localizes to cortical punctate structures. Correct localization requires phosphatidylinositol 4,5- bisphosphate and functional TORC2.
Ptm:		Phosphorylated by the target of rapamycin complex 2 (TORC2) and dephosphorylated by serine/threonine-protein phosphatase 2B (calcineurin). {ECO:0000269\|PubMed:15372071}.
Miscellaneous:		Present with 5190 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.