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PDBsum entry 4a69
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protein ligands metals Protein-protein interface(s) links
Transcription PDB id
4a69

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
369 a.a.
69 a.a.
Ligands
ACT ×2
GOL ×4
I0P ×2
Metals
_ZN ×2
__K ×4
Waters ×347
PDB id:
4a69
Name: Transcription
Title: Structure of hdac3 bound to corepressor and inositol tetraphosphate
Structure: Histone deacetylase 3,. Chain: a, b. Fragment: residues 1-376. Synonym: hd3, rpd3-2, smap45, hdac3. Engineered: yes. Nuclear receptor corepressor 2. Chain: c, d. Fragment: residues 389-480. Synonym: n-cor2, ctg repeat protein 26, smap270, silencing mediator
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f.
Resolution:
2.06Å     R-factor:   0.190     R-free:   0.236
Authors: P.J.Watson,L.Fairall,G.M.Santos,J.W.R.Schwabe
Key ref: P.J.Watson et al. (2012). Structure of HDAC3 bound to co-repressor and inositol tetraphosphate. Nature, 481, 335-340. PubMed id: 22230954
Date:
01-Nov-11     Release date:   11-Jan-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
O15379  (HDAC3_HUMAN) -  Histone deacetylase 3 from Homo sapiens
Seq:
Struc: 		428 a.a.
369 a.a.
Protein chains
Pfam   ArchSchema ?
Q9Y618  (NCOR2_HUMAN) -  Nuclear receptor corepressor 2 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		2514 a.a.
69 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 1: Chains A, B: E.C.3.5.1.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
   Enzyme class 2: Chains A, B: E.C.3.5.1.98  - histone deacetylase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: N6-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate
N(6)-acetyl-L-lysyl-[histone]
 + H2O
 = L-lysyl-[histone]
Bound ligand (Het Group name = ACT)
corresponds exactly 		+ acetate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Key reference    
 
 
Nature 481:335-340 (2012)
PubMed id: 22230954  
 
 
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate.
P.J.Watson, L.Fairall, G.M.Santos, J.W.Schwabe.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23292142 S.H.You, H.W.Lim, Z.Sun, M.Broache, K.J.Won, and M.A.Lazar (2013).
Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.
  Nat Struct Mol Biol, 20, 182-187.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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