PDBsum entry 4a5t

Hydrolase

PDB id: 4a5t

Contents

Protein chain

767 a.a.

Ligands

NGA-GAL-SIA

Metals

_CL ×2

PDB id:

4a5t

Name:

Hydrolase

Title:

Structural basis for the conformational modulation

Structure:

Plasminogen. Chain: s. Synonym: plasmin heavy chain a, activation peptide, angiostatin, plasmin heavy chain a\,short form, plasmin light chain b. Ec: 3.4.21.7

Source:

Homo sapiens. Human. Organism_taxid: 9606

Resolution:

3.49Å R-factor: 0.211 R-free: 0.250

Authors:

Y.Xue,C.Bodin,K.Olsson

Key ref:

Y.Xue et al. (2012). Crystal structure of the native plasminogen reveals an activation-resistant compact conformation. J Thromb Haemost, 10, 1385-1396. PubMed id: 22540246

Date:

28-Oct-11 Release date: 23-May-12

Protein chain

P00747  (PLMN_HUMAN) -  Plasminogen from Homo sapiens

Seq: 810 a.a.

Struc: 767 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.21.7 - plasmin.
• Reaction: Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.

J Thromb Haemost 10:1385-1396 (2012)

PubMed id: 22540246

Crystal structure of the native plasminogen reveals an activation-resistant compact conformation.

Y.Xue, C.Bodin, K.Olsson.

ABSTRACT

No abstract given.