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UniProt functional annotation for P35207 | ||
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| UniProt code: P35207. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
RNA helicase component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon. {ECO:0000269|PubMed:10611222, ECO:0000269|PubMed:10744028, ECO:0000269|PubMed:10922069, ECO:0000269|PubMed:11532933, ECO:0000269|PubMed:11720286, ECO:0000269|PubMed:12769863, ECO:0000269|PubMed:14671320, ECO:0000269|PubMed:363683, ECO:0000269|PubMed:6371496, ECO:0000269|PubMed:7739552, ECO:0000269|PubMed:7739557, ECO:0000269|PubMed:8321235, ECO:0000269|PubMed:9482746}. |
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| Catalytic activity: | |
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; |
| Subunit: | |
Component of the SKI complex composed of at least SKI2, SKI3 and SKI8. The SKI complex interacts with SKI7, which makes the link between the SKI complex and the exosome in order to perform mRNA degradation. {ECO:0000269|PubMed:10744028}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:10744028, ECO:0000269|PubMed:14562095}. |
| Miscellaneous: | |
Present with 5770 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the helicase family. SKI2 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.