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PDBsum entry 4a2j
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Transcription
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PDB id
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4a2j
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PDB id:
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| Name: |
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Transcription
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Title:
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Pr x-ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids
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Structure:
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Progesterone receptor. Chain: a, b. Fragment: ligand binding domain, residues 514-769. Synonym: pr, nuclear receptor subfamily 3 group c member 3. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.00Å
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R-factor:
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0.206
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R-free:
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0.251
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Authors:
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S.J.Lusher,H.C.A.Raaijmakers,R.Bosch,D.Vu-Pham,R.Mcguire,A.Oubrie, J.De Vlieg
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Key ref:
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S.J.Lusher
et al.
(2012).
X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11β-substituted steroids.
J Biol Chem,
287,
20333-20343.
PubMed id:
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Date:
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27-Sep-11
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Release date:
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04-Apr-12
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PROCHECK
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Headers
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References
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P06401
(PRGR_HUMAN) -
Progesterone receptor from Homo sapiens
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Seq:
Struc:
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933 a.a.
250 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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J Biol Chem
287:20333-20343
(2012)
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PubMed id:
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X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11β-substituted steroids.
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S.J.Lusher,
H.C.Raaijmakers,
D.Vu-Pham,
B.Kazemier,
R.Bosch,
R.McGuire,
R.Azevedo,
H.Hamersma,
K.Dechering,
A.Oubrie,
M.van Duin,
J.de Vlieg.
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ABSTRACT
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Links
