PDBsum entry 4a1s

Cell cycle

PDB id: 4a1s

Contents

Protein chains

346 a.a.

30 a.a.

28 a.a.

Waters ×485

PDB id:

4a1s

Name:

Cell cycle

Title:

Crystallographic structure of the pins:insc complex

Structure:

Partner of inscuteable. Chain: a, b. Fragment: tpr-region, residues 1-406. Synonym: pins. Engineered: yes. Other_details: residues 369-386 are built as polyalanine. Re60102p. Chain: c, e. Fragment: pins-binding peptide, residues 301-340.

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: rosetta.

Resolution:

2.10Å R-factor: 0.210 R-free: 0.256

Authors:

S.Culurgioni,A.Alfieri,V.Pendolino,F.Laddomada,M.Mapelli

Key ref:

S.Culurgioni et al. (2011). Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions. Proc Natl Acad Sci U S A, 108, 20998-21003. PubMed id: 22171003

Date:

19-Sep-11 Release date: 28-Mar-12

Protein chains

Q9VB22  (Q9VB22_DROME) -  LD33695p from Drosophila melanogaster

Seq: 658 a.a.

Struc: 346 a.a.*

Protein chain

Q9W2R4  (Q9W2R4_DROME) -  Inscuteable from Drosophila melanogaster

Seq: 859 a.a.

Struc: 30 a.a.

Protein chain

Q9W2R4  (Q9W2R4_DROME) -  Inscuteable from Drosophila melanogaster

Seq: 859 a.a.

Struc: 28 a.a.

* PDB and UniProt seqs differ at 17 residue positions (black crosses)

Proc Natl Acad Sci U S A 108:20998-21003 (2011)

PubMed id: 22171003

Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions.

S.Culurgioni, A.Alfieri, V.Pendolino, F.Laddomada, M.Mapelli.

ABSTRACT

No abstract given.