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PDBsum entry 4a15
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protein dna_rna ligands metals links
Hydrolase PDB id
4a15

 

 

 

 

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Contents
Protein chain
596 a.a.
DNA/RNA
Ligands
SF4
SO4 ×3
Metals
_CA
Waters ×134
PDB id:
4a15
Name: Hydrolase
Title: Crystal structure of an xpd DNA complex
Structure: Atp-dependent DNA helicase ta0057. Chain: a. Synonym: xpd helicase. Engineered: yes. 5'-d( Dtp Ap Cp Gp)-3'. Chain: e. Engineered: yes
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril. Synthetic: yes
Resolution:
2.20Å     R-factor:   0.195     R-free:   0.250
Authors: J.Kuper,S.C.Wolski,G.Michels,C.Kisker
Key ref: J.Kuper et al. (2012). Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation. Embo J, 31, 494-502. PubMed id: 22081108
Date:
14-Sep-11     Release date:   01-Feb-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9HM14  (XPD_THEAC) -  ATP-dependent DNA helicase Ta0057 from Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Seq:
Struc: 		 
Seq:
Struc: 		602 a.a.
596 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

DNA/RNA chain
  T-A-C-G 4 bases

 Enzyme reactions 
   Enzyme class: E.C.3.6.4.12  - Dna helicase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + H2O = ADP + phosphate + H+
ATP
 + H2O
 = ADP
 + phosphate
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
Embo J 31:494-502 (2012)
PubMed id: 22081108  
 
 
Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation.
J.Kuper, S.C.Wolski, G.Michels, C.Kisker.
 
  ABSTRACT  
 
No abstract given.

 

 

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