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UniProt functional annotation for P56199 | ||
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| UniProt code: P56199. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269|PubMed:15592458}. |
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| Subunit: | |
Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21. Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling. {ECO:0000269|PubMed:15592458, ECO:0000269|PubMed:16754960}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Domain: | |
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. |
| Similarity: | |
Belongs to the integrin alpha chain family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.