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PDBsum entry 4a0q
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Cell adhesion
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PDB id
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4a0q
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PDB id:
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| Name: |
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Cell adhesion
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Title:
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Activated conformation of integrin alpha1 i-domain mutant
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Structure:
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Integrin alpha-1. Chain: a, b. Fragment: integrin alpha1 i-domain, residues 166-366. Synonym: cd49 antigen-like family member a, laminin and collagen receptor, vla-1, cd49a. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Resolution:
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1.90Å
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R-factor:
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0.186
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R-free:
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0.229
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Authors:
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M.Lahti,E.Bligt,H.Niskanen,V.Parkash,A.-M.Brandt,J.Jokinen, P.Patrikainen,J.Kapyla,J.Heino,T.A.Salminen
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Key ref:
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M.Lahti
et al.
(2011).
Structure of collagen receptor integrin α(1)I domain carrying the activating mutation E317A.
J Biol Chem,
286,
43343-43351.
PubMed id:
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Date:
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12-Sep-11
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Release date:
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26-Oct-11
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PROCHECK
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Headers
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References
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P56199
(ITA1_HUMAN) -
Integrin alpha-1 from Homo sapiens
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Seq:
Struc:
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1179 a.a.
187 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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J Biol Chem
286:43343-43351
(2011)
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PubMed id:
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Structure of collagen receptor integrin α(1)I domain carrying the activating mutation E317A.
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M.Lahti,
E.Bligt,
H.Niskanen,
V.Parkash,
A.M.Brandt,
J.Jokinen,
P.Patrikainen,
J.Käpylä,
J.Heino,
T.A.Salminen.
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ABSTRACT
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Links
